منابع مشابه
HLA Typing and Celiac Disease in Moroccans
Genetic and environmental factors are responsible for differences in the prevalence of some diseases across countries. Human leukocyte antigen (HLA) allele frequencies in North African populations show some differences in their distribution compared to Europeans, Mediterraneans, and sub-Saharans, and some specific alleles and haplotypes could be clinically relevant. Celiac disease (CD) has been...
متن کاملIs HLA Typing a Diagnostic Tool in Celiac Disease?
The “four out of five rule” has not been officially endorsed by official guidelines. However, HLAassociated genes that predispose to CD are found in as much as 30–40% of healthy people. Thus, their presence seems too indecisive for the occurrence of CD.
متن کاملUse of HLA typing in diagnosing celiac disease in patients with type 1 diabetes.
OBJECTIVE This study examines the use of HLA typing for the diagnosis of celiac disease in a group of Australians with type 1 diabetes. RESEARCH DESIGN AND METHODS Subjects included 131 sequential patients with type 1 diabetes (mean age 17 years [range 10-37]), 77 patients with biopsy-proven celiac disease (mean age 52 years [range 12-84]), and 162 healthy control subjects (mean age 17 years ...
متن کاملAccuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease.
BACKGROUND Estimates of the diagnostic performance of serologic testing and HLA-DQ typing for detecting celiac disease have mainly come from case-control studies. OBJECTIVE To define the performance of serologic testing and HLA-DQ typing prospectively. DESIGN Prospective cohort study. SETTING University hospital. PATIENTS Patients referred for small-bowel biopsy for the diagnosis of cel...
متن کاملHLA genotyping in pediatric celiac disease patients.
Celiac disease (CD) is a chronic inflammatory disease in the small intestine triggered by gluten uptake that occurs in genetically susceptible individuals. HLA-DQ2 protein encoded by HLA-DQA1*05 and DQB1*02 alleles is found in 90-95% of CD patients. All of the remaining patients carry HLA-DQ8 protein encoded by HLA-DQA1*03 and DQB1*03:02 alleles. Specific HLA-DQ genotypes define different risk ...
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ژورنال
عنوان ژورنال: Medical Sciences
سال: 2017
ISSN: 2076-3271
DOI: 10.3390/medsci5010002